As you have probably ascertained from reading these four articles I posted dealing with Alzheimer’s Disease and hormone replacement therapy, it is a very controversial topic.  This is a topic that may create or stir more debate and perhaps studies to come.  Is there a link between development of Alzheimer’s Disease and either taking or not taking hormone replacement therapy?  I don’t blame any person for being more confused after reading these articles.  The last two to three years of reports on this topic has been very confusing for the clinicians and academicians as well.  There are a lot more of these articles that I did not report.  Before WHI and HERS studies were reported, there was such a positive attitude towards hormone replacement therapy, either estrogen alone or combination estrogen and progesterone.  I would suggest to anyone reading this to read the article I have posted on hormone replacement therapy.  I personally believe the WHI studies were flawed, but unfortunately we have to live with these results.  I believe the ACOG report that I posted on HRT sums it up very succinctly.  So, which reports or studies does one believe?  Is there is a link between taking HRT and developing Alzheimer’s or does not taking HRT increase one’s chances of getting Alzheimer’s?  The answer is no one really knows.  What about men who get Alzheimer’s?  Is there a link between lack of androgens and development of Alzheimer’s in men?  If that were demonstrated, then could that also be applied to women and estrogens?   Testosterone and estrogen are both gonadal hormones.  There are some intriguing studies that I have read on this subject in men.  What we may need are more well conducted prospective studies done on women from the onset of menopause, and take these studies out over ten years to determine if there is any statistical significance between the two groups in development of Alzheimer’s.  I have my own opinions about this subject.  I am very pro-hormone in my practice, but as I have stated to my patients too many times.  The patient makes the ultimate decision.  We need some answers soon since my age group, the Baby Boomers, is rapidly approaching the age that Alzheimer’s begins to appear.  We could have an Alzheimer’ s crisis in ten to fifteen years since my age group is so large a group.  Doc